Abstract
This study was performed to evaluate the usefulness of bone tracer 99mTC-MDP in detecting renal disorders by imaging of renal cortex for patients with cortical defect and estimation of split renal function (SRF) as compared with renal cortical imaging agent 99mTC-DMSA. In this study 23 patients (6 males, 17 females) with range age of 16y -75y (mean 45.6y ± 17.4y), and a total of 46 studies (using both 99mTC-DMSA and 99mTC-MDP per patient for left and right kidneys) were performed for detecting renal disorders. Both studies were performed within 48 hours between each other. SRF was calculated in all cases from renal uptake of the tracers into the region of interest by using computer acquired data of gamma camera. For detecting renal cortex abnormalities, all cortical scars and defects scars seen on 99mTc-DMSA scan were also detected by 99mTc-MDP. The results showed that the non visualized kidney on 99mTC-DMSA scan was also non visualized on 99mTC-MDP. Also, there was a high correlation between SRF values obtained from 99mTC-MDP and 99mTC-DMSA, where (p>0.01, r= 0.93 for left kidney and r=0.0.92 for right kidney). The similar SRF values of 99mTC-MDP and 99mTC-DMSA allow to use of 99mTC-MDP tracers for detecting both of bone and renal abnormalities.
Highlights
Estimation of split renal function is a important role of renal scintigraphy [1] and one of the major contributions of radionuclide renal studies to the practice of urology [2]
Functional and morphologic investigations with radionuclide studies play a prominent role in the diagnosis and follow-up of various renal disorders [3,4,5,6,7]. 99mTc- DMSA is slowly cleared from the blood and concentrates in the renal cortex; 42 % of the injected dose remains in the renal cortex at 6 hours [8]
Scanning has been regarded as the best method for assessing split renal function (SRF) because the radiotracer is retained [18], primarily in the proximal convoluted tubules, for a sufficiently long time to allow static imaging of tubular activity which can be performed over several minutes [19]
Summary
Estimation of split renal function is a important role of renal scintigraphy [1] and one of the major contributions of radionuclide renal studies to the practice of urology [2]. Functional and morphologic investigations with radionuclide studies play a prominent role in the diagnosis and follow-up of various renal disorders [3,4,5,6,7]. Because of its high kidney uptake, it has been suggested that 99mTc-DMSA may be the best technetium agent for determining the relative functional renal mass. Technetium-99m dimercaptosuccinic acid (99mTC-DMSA) was introduced in 1974 and is still the agent of choice for static renal scintigraphy [9,10], and 99mTC MDP(methylene diphosphate) labeled phosphate complexes were first introduced in 1971 as a major advance in skeletal image. Many authors [10,11,12,13,14] found that there are a number of renal disorders detected while doing bone scintigraphy because 99mTC-MDP
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Nuclear Medicine & Radiation Therapy
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
