Abstract
Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. Although PVD was historically considered an acute event, recent studies using spectral-domain optical coherence tomography (SD-OCT) revealed a gradual progression of PVD in healthy subjects. Although SD-OCT improved PVD studies, the narrow imaging angle and long examination time were problematic to allow wide angle capture. The Xephilio OCT-S1 (Canon), a swept-source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition. We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Age was significantly positively correlated with the overall PVD stage (ρ = 0.7520, P < 0.001). Interestingly, partial PVD occurred in children as young as 5 years, indicating that initial PVD onset may occur much earlier than previously reported. Furthermore, PVD stages of the bilateral eyes were highly consistent in 183 subjects (85.5%). Widefield 23-mm SS-OCT thus revealed that PVD started earlier than anticipated, and age was correlated with the symmetry of PVD stage. Widefield 23-mm SS-OCT may also be clinically useful for the evaluation of diseased eyes.
Highlights
Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane
Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and the internal limiting membrane caused by vitreous gel liquefaction and weakening of vitreoretinal a dhesion[1]
This study found that in eyes without pathologies, partial PVD can be observed even at age ≤ 10 years and that the PVD stage progressed with age
Summary
Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. The Xephilio OCT-S1 (Canon), a swept-source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Recent studies using spectral-domain optical coherence tomography (SD-OCT) have revealed the gradual and slow progression of PVD in healthy subjects, starting from the paramacular area, extending to the perifoveal area, followed by vitreopapillary separation, and leading to complete PVD6,7. The Xephilio OCT-S1 (Canon, Tokyo, Japan), launched in 2020, is an SS-OCT device that can obtain up to 23 mm of widefield B-scan images in a single acquisition This instrument can detect a wide angle of vitreoretinal interfaces for an accurate assessment of PVD progression in a wide population, including young children. Previous studies on PVD using OCT lacked quantitative assessments and included a possibility of left–right eye differences in PVD progression
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