Abstract
The mucoadhesive properties of three types of nanocellulose (CNF, CNC, and Tempo-CNF) was investigated in the digestive condition with ex vivo and in vitro assays. In the ex vivo flow-through method, three nanocellulose materials showed different levels of retention on porcine gastric and intestinal mucosal surfaces. Fluorescence microscopy confirmed that retention of CNF could be due to entanglement with the mucosal layer, while retention of Tempo-CNF could be due to instantaneous gelling on the mucosal surface. In an in vitro viscometric method, 2% CNC showed the highest viscosity synergism (relative enhancement=11.80 ± 1.14) in the gastric condition, while Tempo-CNF only displayed synergism under gelling concentrations (0.1%). Evaluation of zeta potential revealed that 0.025–0.1% CNC interacted with mucin particles by changing the surface charge of the mucin-nanocellulose system. These results indicate that nanocellulose shows mucoadhesive properties in digestive tract, where the level of adhesion depends on type of nanocellulose, its concentration and the gastrointestinal section.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
