Abstract
Eucalyptus oil has been used since ancient times for its bactericidal, anti-inflammatory, analgesic and sedative effects. In recent years, the action of Eucalyptus oil has been scientifically proven, and there have been reports that Eucalyptus oil suppresses the production of chemokines, cytokines and lipid mediators in basophils, alveolar macrophages and monocytes. Based on this information, we aimed to verify whether Eucalyptus oil can be used for allergic dermatitis, the incidence of which has been increasing among human skin diseases. This effect was verified using a mouse IgE-mediated local allergic model. In conclusion, topical application of Eucalyptus oil suppressed oedema and vascular permeability enhancement due to IgE-mediated allergic on the skin. In addition, we also verified the degranuration of mast cells, which is a part of its action, and examined whether 1,8-cineole, which is the main component of Eucalyptus oil, suppresses the phosphorylation of PLCγ and p38 directly or indirectly. 1,8-cineole was found to suppress degranulation of mast cells.
Highlights
Eucalyptus oil has been used by Australian natives as a remedy for wounds and inflammation[1,2]
Prior to the Eucalyptus oil test, it was verified whether the inhibitory effect can be detected, using sodium cromoglycate, which has an inhibitory effect on mast cell degranulation (Supplementary Fig. 2)
To confirm the usefulness of Eucalyptus oil before starting this test, we conducted a comparative test with Orange oil,Hinokitiol,L-menthol,dl-camphol, γ-oryzanol, etc., which are plant oils known to have degranulation inhibitory effects on basophils[8,39,40], and confirmed the potential of Eucalyptus oil (Supplementary Fig. 1)
Summary
Eucalyptus oil has been used by Australian natives as a remedy for wounds and inflammation[1,2]. Clinical studies confirmed the anti-inflammatory effects of Eucalyptus oil in patients with asthma, such as alleviating sinusitis symptoms and preventing the worsening of chronic obstructive pulmonary d isease[4,5,6,7]. It was reported to improve the skin symptoms of patients with atopic dermatitis[18] Based on this information, we aimed to verify whether or not Eucalyptus oil can be used for allergic dermatitis, the incidence of which has been increasing among human skin diseases. We first evaluated whether Eucalyptus oil suppressed inflammation in an IgE-mediated local allergic model, a model of inflammatory allergic disease caused by mast cell a ctivation[19,20,21]. Mast cells (BMMCs), which revealed that Eucalyptus oil and its main component 1,8-cineole suppressed mast cell degranulation and alleviated allergic dermatitis, supporting their potential as crude medicines for relieving allergic dermatitis
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