Abstract
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients’ demography, geographic locations and season of illness in China.
Highlights
1234567890():,; Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019
influenza virus (IFV), respiratory syncytial virus (RSV), human rhinovirus (HRV), human parainfluenza virus (HPIV), and human adenovirus (HAdV) were frequently identified in patients with either Acute respiratory infections (ARIs) or pneumonia
Among either ARI or pneumonia patients, RSV was identified as the leading pathogen in the child group, which was consistent with findings from the USA6
Summary
1234567890():,; Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients’ demography, geographic locations and season of illness in China. Numerous research studies have reported the detection of respiratory pathogens causing ARIs or pneumonia, with a great diversity in prevalence and pathogen spectrum shown across countries and regions, population demography, years, and seasons[5,6,7,8]. In this work, using these unique data, we identify the etiological and epidemiological features of ARI in all ages of the population of China for an extended duration, immediately prior to the COVID-19 pandemic
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
