Etiological and clinical characteristics of 457 children with lobar pneumonia in Henan

Abstract

Objective To investigate the distribution of respiratory pathogens and its clinical characteristics of lobar pneumonia in children in Henan. Methods A total of 457 cases of large lobar pneumonia were collected from January 2006 to Dcecmber 2016, and there were 1 375 samples collected from these patients, including serum, sputum, pharynx swab and alveolar lavage fluid. Then these specimens were detected by bacteria culture, real time fluorescent reverse transcription-polymerase chain reaction, enzyme-linked immunosorbent assay detection of antibodies and virus isolation, respectively. The age, sex, onset month were analyzed statistically. Results A total of 311 were positive in 457 patients (mycoplasma, bacteria, or virus positive), the positive rate was 68.05% (311/457), the pathogenic mycoplasma positive accounted for 45.66%(142/311), the virus and the bacteria accounted for 29.90%(93/311), 24.44%(76/311) respectively. Children under 3 years old had higher bacterial infections, the mycoplasma infection was higher in preschool age (3-7 years old). The proportion of viral infection was compared with the three age groups, and the difference was not significant (P>0.05). The clinical features of children with lobar pneumonia were higher onset rate in winter and spring. Children under 14 years old were susceptible, there were 165 cases (36.10%) between 3 and 5 years old, and the ratio of male to female was 1.63. Conclusions Lobar pneumonia in children is a multi-pathogen disease in Henan, mainly occurred in preschool and school-age children. Key words: Lobar pneumonia; Adenovirus; Epidemiology