Abstract
Male rats receiving a 15% ( v v ) ethanol solution in place of drinking water for 4 wk showed a significant increase in microsomal O-demethylase activity and a slight rise in P-450 content. DDT and chlorcyclizine administered with food in concentrations of 50 and 250 ppm, respectively, also enhanced the activity of this microsomal enzyme system. When these agents were administered along with ethanol, there was an additional increase in O-demethylase activity and P-450 content. The higher activity of the microsomal enzymes, associated with the ingestion of ethanol, ethanol along with DDT, or ethanol with chlorcyclizine did not seem to affect the rate of ethanol metabolism, as reflected in the production of 14CO 2 from the ethanol-1- 14C. The chronic administration of chlorcyclizine led to a significant reduction in liver alcohol dehydrogenase activity.
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