Abstract
In previous papers, we reported that the activity of drug-metabolizing enzymes was higher in young female rats than in old female rats and that the duration of hexobarbital anesthesia was shorter in the young females than in the old females (1-3). Moreover, it was observed that the induction of microsomal drug-metabolizing enzymes by phenobarbital was more effective in young rats than in old rats (4, 5). In the present communication, we wish to report the evidence that, in contrast to the results obtained with rats, clear age difference was not observed in the activity of drug-metabolizing enzymes in mice and there was no clear age difference in the induction of drug-metabolizing enzymes by phenobarbital.
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