Abstract
The study of propolis and the amniotic membrane as alternatives to promote the acceleration of healing has grown considerably. These products have shown to be easy to use, have bactericidal or bacteriostatic action and are affordable. The objective of the present study was to evaluate the action of the amniotic membrane of bitches and propolis in the healing of surgical wounds. To evaluate the efficacy of these methods the time for conclusion of the healing process of both groups was compared with a control group. In addition, the inflammatory response of each group was also evaluated to identify which alternative method could induce a better response in the healing process compared to the control group. For this purpose, 27 animals, Rattus norvegicus, variety Wistar, were used. Rats were separated into 3 groups with 9 animals each. Group I represented the 25% alcoholic propolis solution; Group II, Amniotic membrane; Group III was Control group. Wounds were assessed macroscopically for the lesion area, and microscopically for the histological quality of each wound layer and the intensity of inflammation and collagen deposition. After the macroscopic analysis, it was observed that there were no statistical differences among the 3 groups (p> 0.05) relevant to accelerate the healing process in terms of presence of inflammatory cells, fibroblasts, collagen, neovascularization, granulation tissue and re-epithelialization.
Highlights
The study of complementary methods that stimulate wound healing is necessary due to the high number of cases the presents this condition in the veterinary medical routine
The proliferative phase is responsible for the closure of the lesion and is marked by fibroplasia, angiogenesis and reepithelization (SUVARNA et al, 2013)
Optimal healing depends on increased granulation, tissue formation, increased fibroblastic proliferation and synthesis of extracellular matrix components, especially collagen (PACHECO, 2016)
Summary
The study of complementary methods that stimulate wound healing is necessary due to the high number of cases the presents this condition in the veterinary medical routine Some characteristics such as capacity of acceleration of healing process, bactericidal action and affordable cost are desired when using these products. Optimal healing depends on increased granulation, tissue formation, increased fibroblastic proliferation and synthesis of extracellular matrix components, especially collagen (PACHECO, 2016). It has been noted in several alternative healing methods that the acceleration of the healing process usually occurs by the reduction of the inflammatory phase, which makes fibrosis and collagen deposition faster (TAGLIARI et al, 2019)
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