Abstract
BackgroundTo discuss the meaning of serum oestradiol monitoring in frozen embryo transfer cycle using hormone replacement without pretreatment with gonadotropin hormone (GnRH) agonist.MethodsThe data from two hundred twelve women undergoing two hundred seventy-four frozen-thawed embryo transfer (FET) cycles was included in this retrospective cohort study. They were detected of serum oestradiol levels and endometrium thicknesses during hormone supplement FET cycles and compared their pregnancy outcomes according to their oestradiol level on progesterone initiation day.ResultsPatients with different levels of serum oestradiol (percentile 0–25th, 25th–75th and 75th–100th) on progesterone initiation day yielded the endometrium thickness of 9.3 ± 0.12, 8.9 ± 0.07 and 9.1 ± 0.11 mm(P > 0.05) and the pregnancy rate of 32.2%, 38.4% and 36.3% (P > 0.05) respectively.ConclusionThe serum estradiol level did not predict pregnancy success in hormone replacement FET cycles, suggesting that oestradiol monitoring in this method of endometrial preparation is unnecessary.
Highlights
To discuss the meaning of serum oestradiol monitoring in frozen embryo transfer cycle using hormone replacement without pretreatment with gonadotropin hormone (GnRH) agonist
Frozen embryo transfer in women with functioning ovaries can be timed with ovulation in natural cycle or after artificially preparing the endometrium with exogenous hormones
The aim of pretreatment with GnRHa is to avoid spontaneous ovulation, but it is costly and there is a risk of hypoestrogenic side effect that would lengthen the preparation
Summary
Patients From January 2004 until July 2007, all the patients who underwent the transfer of their frozen-thawed embryos that were cryopreservated in previous IVF or ICSI cycle and preferred hormone replacement protocol were included in this retrospective study. Embryo freezing-thawing On the 3rd day after oocyte retrival, fresh cleavage-stage embryos generated using IVF or ICSI were assessed and assigned using a standardized scoring system: A) number of blastomeres (BL) was divided into four categories: 1 = four BL, 2 = five BL, 3 = six to seven BL and 4 = eight to ten BL. Hormone assay Serum level of FSH (IU/L), LH (IU/L), E2 (pg/ml) and P (ng/ml) were measured in all patients on the day of E initiation (day 2), LH and E2 levels were measured on the days ultrasound was done, the day of P administration and the day of ET.
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