Abstract
Exo-endocytotic images and intramembrane particles were quantitatively assessed in freeze-fracture replicas from the plasma membrane of dispersed fetal rat cortical neurons (day 16 gestation) grown for 24 days in culture. The addition of 10 −10 M 17β-estradiol to the culture medium resulted in a significant increase in the numerical density of exo-endocytotic images within 1 min. A further increase of the number of exo-endocytotic images associated to a significant decrease in the number of intramembrane particles was observed in cells exposed for 10 min to 17β-estradiol. Similar results were observed when the cells were exposed to 17β-estradiol for 17 days. No effects on exo-endocytotic images and intramembrane particles were observed when 17α-estradiol was added, instead of 17β-estradiol, to the cultures. These results indicate that physiological levels of 17β-estradiol can have rapid effects upon the ultrastructure of the neuronal membrane of developing cerebrocortical neurons.
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