Abstract
The influence of sex steroids on myocardial superoxide dismutase (SOD) activity was evaluated in rabbits. No sex differences in SOD activity were observed in male and female rabbits. Castration did not lead to any changes in SOD activity in either sex. Graded doses of estradiol that produced graded increases in uterotropic effect failed to produce any change in myocardial SOD activity. Results indicate that the beneficial effect of estrogen on cardiovascular disease and the sex differences in incidence of cardiovascular morbidity cannot be explained on the basis of a direct action of estradiol on myocardial SOD activity.
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