Abstract
Abstract (1) Uptake of estradiol into cell nuclei of the anterior hypothalamus and uterus (females) was studied in normal male, normal female, and neonatally androgen treated (androgenized) adult female rats. (2) In the uterus, the addition of excess cytosol to homogenates of similar tissue in incubation increased nuclear uptake of estradiol in normal but not in androgenized females. (3) In the hypothalamus, the addition of excess cytosol to homogenates of similar tissue in incubation increased nuclear uptake of estradiol to similar levels in normal females, normal males and androgenized females. (4) The addition of excess cytosol from normal uterus or hypothalamus to homogenates of androgenized uterus or hypothalamus (respectively) consistently increased nuclear uptake of estradiol during incubation. (5) The data suggest that androgens act during a critical period of hypothalamic differentiation to alter the mechanism for intracellular transport of estradiol.
Published Version
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