Estimation of Uric Acid Level for the Assessment of the Severity of Diseases with Clinically Diagnosed Sepsis

Abstract

Background and Aim: The incidences of sepsis and septic shock depend on how acute organ dysfunction and infection are defined as well as on which data sources are studied. Hence this study was conducted to bring out the correlation between hyperuricemia in clinically diagnosed sepsis patients and morbidity and mortality. Material and Methods: Total of 150 patients was included in the study. For the uric acid estimation of the included patients; blood samples were taken from the patient. For the biochemical estimation of the uric acid level the collaboration was done with the department of biochemistry, medical college and hospital. Results: Among the 150 study participants, 64 patients had elevated uric acid levels which constitutes about 42.7%, whereas 86 patients constituting 57.3% had normal uric acid levels. It can be inferred that among the study population, patients had type 2 diabetes mellitus as the most common comorbidity at 40%. The most prevalent comorbidities among the patients with hyperuricemia were diabetesmellitus type 2 and type 1, decompensated liver disease and cerebrovascular accident. Patients without any comorbidities about 36% of the study population also developed sepsis. Conclusion: This study demonstrates that Serum Uric acid may be potentially used as a marker of severity of illness as well as predictor of mortality and morbidity in patients with clinically diagnosed sepsis in the IMCU. This study recommends further studies on a large basis to confirm the observations.