Estimation of serum uric acid, urinary calcium-creatinine ratio and microalbuminuria in prediction of pre-eclampsia

Abstract

Introduction: The present study was aimed at evaluating serum uric acid, urinary calcium to creatinine ratio and microalbuminuria as predictors of pre-eclampsia in asymptomatic pregnant females. Materials and Methods: 100 asymptomatic pregnant females were screened for uric acid, urinary calcium to creatinine ratio and microalbuminuria between 20-24weeks of their gestation and were followed up till delivery. BP was recorded and proteinuria evaluated by dipstick method. Our observations were subjected to statistical analysis by evaluating diagnostic accuracy and Receiver Operating Characteristic curve of uric acid, urinary calcium to creatinine ratio and microalbuminuria. Results:Calcium creatinine ratio (94%) and microalbuminuria (89%) turned out to have good specificity, negative predictive value remained high for calcium creatinine ratio (97%), microalbuminuria (95%) and serum uric acid (91%). Area under the curve for calcium creatinine ratio is highest when compared to microalbuminuria and serum uric acid, making it an excellent predictor. Conclusion: Our study findings suggest that calcium creatinine ratio was an excellent predictor of preeclampsia followed by microalbuminuria which was a good test for preeclampsia and serum uric acid which turned out to be a fair predictor of preeclampsia. We conclude that calcium creatinine ratio and microalbuminuria as early predictors of preeclampsia and can be used for screening purpose. Keywords: Pre-Eclampsia, Serum Uric Acid, Microalbuminuria, Urinary Calcium-Creatinine Ratio