Estimation of pulse wave velocity in main pulmonary artery with phase contrast MRI: Preliminary investigation

Abstract

To assess the feasibility and reproducibility of a noninvasive MRI method to measure pulse wave velocity (PWV) in the main pulmonary artery (MPA). A total of 17 subjects without history of pulmonary diseases (38.2 +/- 18.4 years) participated in this study. Series of MR velocity maps of the MPA were acquired at 2 cm above the pulmonary valves using a two-dimensional phase-contrast sequence. Effective temporal resolution was 11 msec after interleaving two dynamic series with different values of electrocardiograph (ECG) trigger delay. PWV was derived as the rate of MPA flow variations per unit change in MPA cross-sectional area, during early systole. Seven healthy subjects underwent three repetitive examinations to investigate intrascan and interscan reproducibility. Flow vs. area was highly linear in the MPA during early systole, with Pearson's coefficients ranging from 0.982 to 0.999, rendering derivation of PWV with little difficulty. Average value of PWV in MPA was 1.96 +/- 0.27 m/second, in good agreement with literature values measured using invasive means. The percentage intra- and interscan differences were 5.46% and -10.86%, respectively. Phase-contrast MRI to noninvasively measure PWV in the MPA is feasible with good reproducibility.