Abstract
The amino acid compositions of many of the known sequenced proteins were compared to determine if a relationship exists between the amino acid composition and the amount of sequence homology of these proteins. For this purpose, a function, the composition divergence, was defined. A computer program based on relatively simple assumptions has been successfully used to simulate the data distribution found in comparing composition divergence with the sequence dissimilarity. From this characterization of known proteins, it is possible to predict the sequence homology of unsequenced proteins, based on amino acid composition comparisons. The power and limitations of this technique are discussed.
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