Estimation of peroxisome proliferators – activated receptor γ gene expression in inflammatory skin diseases: atopic dermatitis and psoriasis

Abstract

Introduction: Peroxisome proliferators- activated receptors (PPARs) represent a major research target for the understanding and treatment of many skin diseases, such as benign epidermal tumors, psoriasis and atopic dermatitis. Aim: Estimate and analyze the PPAR gamma expression and its pathological role in psoriasis and atopic dermatitis. Materials and Methods: Fifteen patients with atopic dermatitis, fifteen patients with psoriasis and twenty apparently healthy subjects as controls,were included in the current study. We estimate the PPARgamma gene expression in the lesional skin of atopic and psoriatic patients and control, by quantitative real-time RT-PCR. Results: Our data showed a significant decreased PPARgamma expression in lesional skin of atopic dermatitis patients and psoriatic patients (P value<0.001) compared to the control group, and the decrease was more marked in the psoriatic patients (P value<0.001). Conclusion: Abberent PPAR γ expression has an important role in the pathogenesis of psoriasis and atopic dermatitis through the affection of cell proliferation, differentiation and inflammation.