ESTIMATION OF PARACETAMOL AND LORNOXICAM BY ISOCRATIC, GRADIENT, AND ELEVATED TEMPERATURE HPLC USING PROPYLENE CARBONATE

Abstract

Propylene carbonate (4-methyl-1,3-dioxolan-2-one) is a five-membered cyclic alkylene carbonate with the chemical formula C4H6O3. It is most commonly used as a solvent for various synthetic polymers and as an electrochemical solvent. Until this date, few RP-HPLC methods have been developed using propylene carbonate as a mobile phase component. This paper aims to further demonstrate the use of Propylene carbonate in RP-HPLC. Three methods have been developed for the simultaneous estimation of Paracetamol and Lornoxicam in combined dosage forms. All these methods use Propylene carbonate as a mobile phase component but in different proportions. Method I is an isocratic RP-HPLC method, Method II uses a solvent gradient program, whereas Method III uses high temperature for the separation of the two drugs.