Abstract
The present work describes an isocratic, simple, accurate and precise RP-HPLC method for the simultaneous estimation of Atorvastatin calcium and Clopidogrel Bisulphate in combined capsule dosage forms. Waters HPLC System with 515-HPLC Pump, Spherisorb 5μ silica (4 × 250mm i.d.) column and PDA-2998 detector was used for the analysis. The mobile phase consisting of Acetonitrile and 0.1% ortho-phosphoric acid in the ratio of 65: 35% v/v was used for the separation of drugs. The mobile phase flow rate was 1ml/min and the eluents were detected at 245nm. Using the optimized chromatographic conditions, resolved sharp peaks corresponding to Atorvastatin Calcium and Clopidogrel Bisulphate could be obtained at retention time of 2.007 and 5.977min respectively. The method was validated in terms of linearity, precision and accuracy.
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