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Abstract
A physiologically based computer model of drug and tracer kinetics in humans was constructed. It includes detailed models of drug distribution kinetics in organs arranged according to the circulatory structure of the body. The system does not contain well-mixed compartments. Basic pharmacokinetic parameters were estimated by fitting a sum of three to fife exponentials to error-free data using different weights in a weighted least squares analysis. The effect of model misspecification was minimised by weighting proponional to l/C2i and/or by an increase of the number of exponential terms.
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