Abstract
The skin is the largest organ of the human body and serves distinct functions in protecting the body. The viscoelastic properties of the skin play a key role in supporting the skin-healing process, also it may be changed due to some skin diseases. In this study, high-frequency ultrasound (HFUS) elastography based on a Lamb wave model was used to noninvasively assess the viscoelastic anisotropy of human skin. Elastic waves were generated through an external vibrator, and the wave propagation velocity was measured through 40MHz ultrafast HFUS imaging. Through the use of a thin-layer gelatin phantom, HFUS elastography was verified to produce highly accurate estimates of elasticity and viscosity. In a human study involving five volunteers, viscoelastic anisotropy was assessed by rotating an ultrasound transducer 360°. An oval-shaped pattern in the elasticity of human forearm skin was identified, indicating the high elastic anisotropy of skin; the average elastic moduli were 24.90±6.63 and 13.64±2.67kPa along and across the collagen fiber orientation, respectively. The average viscosity of all the recruited volunteers was 3.23±0.93Pa·s. Although the examined skin exhibited elastic anisotropy, no evident viscosity anisotropy was observed.
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