Abstract
In the early detection of cancer, the study of genetic lesions, as indicated for example, by micronuclei counts, is very important. One of the most common factors causing such cell damage is some chemical agent, such as ethylene oxide. However, in the study of such cases, the samples obtained will involve mixtures of affected and unaffected cells. If the counts of micronuclei in the affected cells are assumed to follow a Poisson distribution, an estimate of the proportion of affected cells can be obtained from a log-linear model representation of a truncated Poisson distribution. If over-dispersion is present, the same procedure may be followed by using a double Poisson distribution. An example of application of the model is given for two subjects exposed to ethylene oxide and observed periodically over the following year.
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