Estimating the correlation between TYG and CIMT in non-diabetic adult patients

Abstract

Atherosclerosis occurs due to hyperlipidemia and lipid oxidation and is a major cause of death worldwide. This study was conducted to assess the correlation between the TyG index and CIMT and to estimate the predictive value of the TyG index as an early marker of subclinical atherosclerosis. This cross-sectional study was done at JLN Medical college, Ajmer tertiary care centre of central Rajasthan, North India, from December 2019 to June 2021 on 137 Non- Diabetic Males and Females of Age >18 and < 65 years patients. Detailed history, thorough clinical examination and relevant investigations were done to collect data. TyG index and CIMT were calculated. Participants were divided into two groups: Group 1- CIMT>0.9mm (having subclinical atherosclerosis) and Group 2- CIMT≤0.9mm. Mean age and BMI of participants in group 1 and group2 was 50.94yrs; 45.87yrs(P < 0.001), 28.97kg/m2; 26.56 kg/m2 (P = 0.002) respectively. Mean FBS and TG of group 1 and group 2 was 101.33mg/dl; 87.80mg/dl (P < 0.001), 210mg/dl; 156.15mg/dl (P value < 0.001) respectively. The mean TyG index in group 1 was 4.97 and in group 2 was 4.74 (P < 0.001). By receiver operating characteristic (ROC) curve analysis, the cut off value for TyG index is 4.87 (sensitivity = 94.4%, specificity = 94.2%, AUC = 0.887; P value < 0.001). We observed significant positive correlation between CIMT & TyG index (Pearson coefficient +0.675; p value < 0.001). TyG index is a reliable marker for predicting subclinical atherosclerosis at an early stage. • Atherosclerosis occurs as a result of hyperlipidemia and lipid oxidation. • This research estimated its predictive value of TyG index and CIMT as a diagnostic of atherosclerosis. • TyG index is a reliable marker for predicting subclinical atherosclerosis at early stage.