Triglyceride-glucose index is a predictive index of hyperuricemia events in elderly patients with hypertension: a cross-sectional study

Abstract

ABSTRACT Background To analyze the association between triglyceride-glucose index (TYG index) and hyperuricemia (HUA) in elderly patients with hypertension. Methods A total of 428 inpatients with primary hypertension from March 2018 to March 2021 in Qinghai Provincial People’s Hospital were retrospectively analyzed. Grouped by sex and serum uric acid. Serum uric acid (SUA), fasting blood glucose (FPG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum creatinine (Scr), urea nitrogen (BUN), triglycerides (TG), high-sensitivity C-reactive protein (HS-CRP) and other biochemical indicators were measured, and the TYG index was calculated. The TYG index and SUA levels of each group were compared, and the correlation between TYG index and hyperuricemia was analyzed. Multivariate Logistic regression was performed to analyze the relationship between TYG index and the risk of HUA in elderly patients with hypertension. The ROC curve was used to evaluate the predictive value of TYG index in elderly patients with hypertension associated with HUA. Results TYG index was significantly higher in the HUA group than in the normal group in both men and women (P < .05). Spearson correlation analysis showed that TYG index positively correlated with TC, TG, FPG, SUA, and LDL-C(r = 0.327, 0.975, 0.412, 0.214, 0.215, P = .000, 0.000, 0.000, 0.000, 0.000), and negatively correlated with age and HDL-C (r = −0.166, −0.248, P = .001, 0.000). Logistic regression analysis showed that Scr, BUN, HS-CRP and TYG index were the risk factors for HUA in elderly patients with hypertension (P < .05).The ROC curve showed an area under the TYG exponential curve of 0.617(95%CI:0.561 ~ 0.673) with a sensitivity of 64.4% and a specificity of 57.4%. Conclusion TYG index in elderly hypertensive patients is closely related to hyperuricemia, and the increase of TYG index is an independent risk factor for HUA in elderly hypertensive patients.