Establishment of a hybrid cell system between malignant Burkitt's lymphoma cells and nonmalignant lymphoblastoid cells.

Abstract

Burkitt’s lymphoma (BL) is a high-grade malignant B-cell lymphoma found in a high-incidence endemic form in equatorial Africa and a rare sporadic form [1]. This tumor is strongly associated with a viral infection and specific chromosomal translocations. In the vast majority of endemic BL, Epstein-Barr virus (EBV) DNA has been demonstrated [2]. In all BLs one of three specific translocations is present, involving the cellular oncogene c-myc on chromosome 8 and loci for immunoglobulin genes on chromosomes 14, 22, and 2 [3]. The deregulation of c-myc caused by these translocations and the EBV infection are thought to be the critical steps in the development of EBV- positive BL, although the precise mechanisms are still unclear.KeywordsRestriction Fragment Length Polymorphism AnalysisHybrid CloneNonmalignant CellSpecific Chromosomal TranslocationNonmalignant Cell LineThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.