Abstract
BackgroundThe major infectious diseases of hepatitis B has constituted an acute public health challenge in China. An effective and affordable HBV control model is urgently needed. A national project of Community-based Collaborative Innovation HBV (CCI-HBV) demonstration areas has optimized the existing community healthcare resources and obtained initial results in HBV control.MethodsBased on the existing community healthcare network, CCI-HBV project combined the community health management and health contract signing service for long-staying residents in hepatitis B screening. Moreover, HBV field research strategy was popularized in CCI-HBV areas. After screening, patients with seropositive results were enrolled in corresponding cohorts and received treatment at an early stage. And the uninfected people received medical supports including health education through new media, behavior intervention and HBV vaccinations. In this process, a cloud-based National Information Platform (NIP) was established to collect and store residents’ epidemiological data. In addition, a special quality control team was set up for CCI project.ResultsAfter two rounds of screening, HBsAg positive rate dropped from 5.05% (with 5,173,003 people screened) to 4.57% (with 3,819,675 people screened), while the rate of new HBV infections was 0.28 per 100 person-years in the fixed cohorts of 2,584,322 people. The quality control team completed PPS sampling simultaneously and established the serum sample database with 2,800,000 serum samples for unified testing.ConclusionsCCI-HBV project has established a large-scale field research to conduct whole-population screening and intervention. We analyzed the HBsAg prevalence and new infection rate of HBV in the fixed population for the epidemic trend and intervention effect. The purpose of CCI-HBV project is to establish and evaluate a practical model of grid management and field strategy, to realize the new goal to control hepatitis B in China. To provide policymakers with a feasible model, our results are directly applicable.Trial registrationThe project was funded by the Major Projects of Science Research for the 11th and 12th five-year plans of China, entitled “The prevention and control of AIDS, viral hepatitis and other major infectious diseases”, Grant Nos. 2009ZX10004901, 2011ZX10004901, 2013ZX10004904, 2014ZX10004007 and 2014ZX10004008.
Highlights
The major infectious diseases of hepatitis B has constituted an acute public health challenge in China
The lack of Hepatitis B Virus (HBV) vaccinations in adults was responsible for HBV epidemic, indicating that national HBV vaccination for whole population holds greater promise for long-term treatment. [5, 6] we conducted this Community-based Collaborative Innovation (CCI)-HBV field research to explore a series of questions: the cause of HBV high prevalence in China, the different prevention strategies for different groups, the prognosis of HBV carriers, and the way to achieve periodic follow-up in local residents
The selection of CCI areas was based on these factors: the disease burden, epidemiological characteristics, geographic and demographic features, and preliminary community healthcare foundations
Summary
The major infectious diseases of hepatitis B has constituted an acute public health challenge in China. A national project of Community-based Collaborative Innovation HBV (CCI-HBV) demonstration areas has optimized the existing community healthcare resources and obtained initial results in HBV control. In 2009, we initiated the Community-based Collaborative Innovation (CCI) project for the prevention and control of major infectious diseases including AIDS, hepatitis B and TB, which were in the list of Major Special Projects in the National Medium- and Long-term Program for Science and Technology Development (2006–2020) in China. [4] In January 2006, Chinese National Health Department added HBV to National Disease Control and Prevention Plan List, indicating that HBV control was crucial for infectious diseases control in China. [5, 6] we conducted this CCI-HBV field research to explore a series of questions: the cause of HBV high prevalence in China, the different prevention strategies for different groups, the prognosis of HBV carriers, and the way to achieve periodic follow-up in local residents The lack of HBV vaccinations in adults was responsible for HBV epidemic, indicating that national HBV vaccination for whole population (including infants and adults) holds greater promise for long-term treatment. [5, 6] we conducted this CCI-HBV field research to explore a series of questions: the cause of HBV high prevalence in China, the different prevention strategies for different groups, the prognosis of HBV carriers, and the way to achieve periodic follow-up in local residents
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