Abstract
The lecture is focused on the exploration of genetic and physiological mechanisms of essential systemic hypertension (ESH). A very brief historic review is provided on the first clinical meanings of the ESH. Then some speculation provided, on its etiology, evolutionary-genetic roots regarding the formation of the main BP regulation systems. More detailed, the data is shown on genetic base of hypertensive conditions and ESH. Also, some discussion given on the monogenic forms of arterial hypertension and polygenic fundamentals of ESH, which is the most among hypertension conditions of human. Modern methods considered for genetic origins of ESH evaluation, and a necessity is underlined for the main etiological factors revealing — as of their interrelation for development of rational treatment and prevention methods against ESH.
Highlights
Материал лекции посвящен рассмотрению генетико-физиологических механизмов гипертонической болезни (ГБ)
The lecture is focused on the exploration of genetic and physiological mechanisms of essential systemic hypertension (ESH)
A very brief historic review is provided on the first clinical meanings of the ESH
Summary
Материал лекции посвящен рассмотрению генетико-физиологических механизмов гипертонической болезни (ГБ). Если в анамнезе таких пациентов имеется перенесенный мозговой инсульт или коронарная болезнь, а также при наличии высокого риска возможных осложнений целевой уровень для снижения систолического АД должен опускаться ниже 140 мм рт.ст. Такая сложная и многоуровневая система конт роля АД, действительно, предполагает наличие обширной генетической базы, определяющей функцию всех регуляторных систем, и утверждение о том, что практически все гены принимают участие в регуляции АД, наверное, отражает действительную картину.
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