Abstract
Abstract—Scleromyxedema is a type of mucinosis characterized by the presence of lichenoid papules and diffuse induration of the skin. In many cases, it is associated with monoclonal gammopathy and systemic disorders. Histologically, mucin deposits are observed in the dermis, as is a variable degree of fibrosis. We describe a new case in which we have had the opportunity to study its evolution over a 15-year period. This was a 55-year-old female patient. The cutaneous symptoms began 15 years ago, in the form of lichenoid papules in the typical locations, with edema and hardening of the skin. It was accompanied by IgG lambda monoclonal gammopathy. The disease slowly and progressively worsened, with accentuation of the skin and systemic lesions that made a normal life impossible. She has received different treatments, only responding initially to chlorambucil and later to the association of cycles of melphalan/prednisone.
Published Version
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