Escitalopram combined with aripiprazole in the treatment of 46 patients with obsessive compulsive disorder

Abstract

Objective To observe and explore the clinical efficacy and safety of escitalopram combined with aripiprazole in the treatment of obsessive-compulsive disorder.Methods 97 patients with obsessive-compulsive disorder were randomly divided into two groups,control group of 51 patients were given oral administration of escitalopram treatment,46 patients in the experimental group received escitalopram and oral aripiprazole treatment.At the end of treatment,the clinical efficacy and adverse events were evaluated.Results In control group and experimental group patients overall effective rate was 68.6％,89.1％ ;The experimental group the total effective rate was higher than the control group,the difference between two groups was statistically significant( x2 =12.32,P ＜0.05 ),The control group and experimental group after treatment Y-BOCS scores were (23.68 ± 2.74 ) points,( 21.82 ± 2.88 ) points ; The experimental group after treatment Y-BOCS score was significantly better than the control group,between the two groups the difference was statistically significant ( t =2.64,P ＜ 0.05 ) ; While after treatment the TESS score and incidence of adverse reactions between the two groups were not statistically different ( t =0.61 ; x2 =0.03,all P ＞ 0.05 ).Conclusion Escitalopram combined with aripiprazole in the treatment of obsessive compulsive disorder obtain excellent effect,had few adverse reactions,and was worthy of clinical application. Key words: Escitalopram; Aripiprazole; Compulsive personality disorder; Treatment outcome