Abstract
Escherichia coli Soft Metal Ion-translocating ATPases
Highlights
A thorough description of soft metal metabolism requires knowledge of the pathways of entry and efflux of these metals into and out of cells
Ing ATPases of E. coli, and similar systems have been identified in many prokaryotes
No copper uptake systems have been identified in E. coli
Summary
A thorough description of soft metal metabolism requires knowledge of the pathways of entry and efflux of these metals into and out of cells. PhoS is a 34-kDa periplasmic binding protein; the 32-kDa PstA and the 34-kDa PstC form the membrane complex; the 29-kDa PstB is the ATPase subunit of the transport system. Efflux of soft metal ions is catalyzed by specific transport ATPases. As(III) and Sb(III) are extruded by the ArsAB ATPase, a novel pump with similarities to ABC transporters [12].1 The best characterized system is the one encoded by the arsRDABC operon of E. coli plasmid R773 [13].
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