Abstract
COBALT in the form of one of its salts, usually cobaltous chloride or cobaltous nitrate, has been shown to produce polycythemia in amphibia, birds and mammals.1 2 3 In mammals the increased concentration of red blood cells in the circulation is due, as in other types of polycythemia, largely to an increase in the circulating red-cell mass.4 , 5 That the polycythemia is produced by increased red-cell production is indicated by an initial or by a maintained reticulocytosis,6 , 7 and an increase in erythroid cells in the bone marrow8 , 9 and in extramedullary locations.9 In some species the slight bilirubinemia7 presumably results from a partially compensatory . . .
Published Version
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