Abstract
A new class of sulfone/sulfonamide-linked bis(oxadiazoles), bis(thiadiazoles), and bis(triazoles) were prepared from the synthetic intermediates sulfonyldiacetic acid, arylsulfonylacetic acid hydrazide, and arylaminosulfonylacetic acid hydrazide adopting simple and versatile synthetic methodologies. All the new compounds were tested for their antioxidant activity. Amongst all the tested compounds, methyl-substituted bis(oxadiazoles) (8b and 11b) were found to be potential antioxidant agents. It was also observed that sulfonamide-linked bis(oxadiazoles), bis(thiadiazoles), and bis(triazoles) showed comparatively higher antioxidant activity than sulfone-linked bis(oxadiazoles), bis(thiadiazoles), and bis(triazoles).
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