Abstract
Currently, there is an urgent question of optimizing the treatment of stomach diseases associated with Helicobacter pylori, due to the increasing resistance of the pathogen to antibiotics and the presence of side effects of standard therapy. To optimize it, it is proposed to use probiotics as an additional or monotherapy. The review presents the results of studies of anti-helicobacter activity by in vitro and in vivo systems, as well as an assessment of the clinical effectiveness of various probiotic strains of microorganisms in eradication therapy. Several mechanisms of action of probiotics in the treatment of HP-related diseases are discussed. The problems and prospects of using personalized therapy of helicobacteriosis with probiotics and autoprobiotics, based on strains obtained from the gastrointestinal tract, are indicated.
Highlights
there is an urgent question of optimizing the treatment of stomach diseases associated with
The review presents the results of studies of anti-helicobacter activity
on strains obtained from the gastrointestinal tract
Summary
There is an urgent question of optimizing the treatment of stomach diseases associated with Helicobacter pylori, due to the increasing resistance of the pathogen to antibiotics and the presence of side effects of standard therapy. The review presents the results of studies of anti-helicobacter activity by in vitro and in vivo systems, as well as an assessment of the clinical effectiveness of various probiotic strains of microorganisms in eradication therapy. Тем экспериментальная и клиническая гастроэнтерология | No 193 (9) 2021 experimental & clinical gastroenterology | No 193 (9) 2021 не менее до сих пор не дано рекомендаций о направлениях поиска таких штаммов и ни один из используемых пробиотиков не может быть предложен в качестве универсального или даже оптимального средства для эрадикационной терапии хеликобактериоза. Целями настоящего обзора явились анализ результатов исследований антихеликобактерной активности различных пробиотических штаммов в экспериментальных условиях in vitro и in vivo, а также оценка эффективности эрадикационной терапии хеликобактериоза с применением пробиотиков
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