Abstract
The purpose of this study was to investigate the interaction between phosphatidylcholine (PC) and ergosterol (ERG) in monolayers at the air–water interface. We measured the surface tension of pure and mixed lipid monolayers at 22 °C using the Langmuir method with a Teflon trough and Nima 9002 tensiometer. Surface tension values were used to calculate π-A isotherms and determine molecular surface areas.Interactions between PC and ERG caused significant deviation from the additivity rule. The theory described in this paper was used to determine a stability constant reflecting the area occupied by one molecule of the PC–ERG complex and the complex formation energy (Gibbs energy).
Published Version
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