Epstein-Barr virus is not detected in mucosal lichen planus.

K Danielsson,E Nylander,M Sjostrom,M Ebrahimi

doi:10.4317/medoral.22617

K Danielsson, E Nylander + Show 2 more

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https://doi.org/10.4317/medoral.22617

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Abstract

BackgroundLichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. World Health Organization (WHO) classifies OLP as a potentially malignant disorder. Epstein Barr virus or human herpesvirus-4, is a member of the herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world’s adult population. The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggressive malignancies. The aim of this study was to investigate expression of the EBV encoded RNAs EBER1 and EBER2 in oral and genital lichen planus and compare results with normal tissues in situ hybridization which is considered the golden standard for detection of EBER.Material and MethodsA total of 68 biopsies, 25 oral LP, 26 genital LP, 10 oral controls and finally 7 genital controls were analysed using situ hybridization.ResultsAll samples had RNA as shown by the control slide, whereas no case contained neither EBER1 nor EBER2.ConclusionsBased on results from our study EBV is not involved in aetiology of lichen planus. Key words:Mucosal lichen planus, Epstein - Barr virus.

Highlights

Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease with different clinical appearances [1,2]
EBV or human herpesvirus-4, is a member of herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world’s adult population
The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggressive malignancies [12]

Summary

Introduction

Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease with different clinical appearances [1,2]. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory disease affecting 1-2% of the general adult population [4] but the range of prevalence varies among different populations in the world [3]. Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. The aim of this study was to investigate expression of the EBV encoded RNAs EBER1 and EBER2 in oral and genital lichen planus and compare results with normal tissues in situ hybridization which is considered the golden standard for detection of EBER. Conclusions: Based on results from our study EBV is not involved in aetiology of lichen planus

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