Abstract
EPR studies pointed out that o-semiquinone free radicals with g-values 2.0038–2.0040 take part in moxifloxacin–melanin complex formation. The process contributed to increase in free radicals concentration in nonirradiated complexes. This effect was observed for the complexes with 1×10−4M, 1×10−3M and 4×10−3M drug concentrations. UV irradiation contributed to decrease in free radicals concentration in DOPA–melanin complexes with moxifloxacin, besides the complexes with the drug concentration of 1×10−4M. The strongest decrease was observed for DOPA–melanin–moxifloxacin complexes with the drug concentration of 1×10−3M. Homogeneous broadening of EPR lines, strong dipolar interactions and slow spin–lattice relaxation processes characterized all the tested melanin samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
