Abstract
DOPA–melanin and its complexes with netilmicin and metal ions (Zn 2+,Cu 2+) were examined by EPR spectroscopy. Broad EPR lines of o-semiquinone free radicals and paramagnetic Cu 2+ were measured. Netilmicin slightly increased free radicals concentration in DOPA–melanin. Diamagnetic Zn 2+ and paramagnetic Cu 2+ ions increased and decreased, respectively, free radical concentrations in melanin–netilmicin complexes. Higher free radical concentrations were determined for (melanin–Zn 2+)–netilmicin complexes than for (melanin–netilmicin)–Zn 2+. Free radical concentrations were lower in (melanin–Cu 2+)–netilmicin complexes than in (melanin–netilmicin)–Cu 2+. Slow and fast spin–lattice relaxation processes were found for free radicals and Cu 2+ systems in the samples. Netilmicin and Cu 2+ increased spin–lattice relaxation time in melanin.
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