Abstract

Chromatography of an ethyl acetate extract of the fruits of Rollinia mucosa led to the isolation of two new γ-lactone acetogenins, epomusenins A and B, which are the first examples of the rare C 37-type annonaceous acetogenins having an epoxide and a double bond along the aliphatic chain in place of the usual tetrahydrofuran moeity. The three known acetogenins, rolliniastatin-1, rolliniastatin-2 and squamocin were also isolated. The structures were established by means of one and two dimensional NMR experiments.

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