Abstract
Several types of tumors affect dogs' skin. Simultaneously occurring neoplasms with different histological patterns might be rarely present in the same animal. This paper describes the occurrence of epitheliotropic cutaneous T-cell lymphoma and melanoma in a dog. The animal had nodular lesions in the abdominal region and serpiginous plaques on the dorsal region of the trunk. Cytology evidenced malignant fusiform cells from the abdominal lesions as well as few round cells from the dorsal. The histopathological examination of the abdominal lesions showed dermis with polygonal to spindle-shaped neoplastic cells. The lesion of the dorsal region evidenced neoplastic round cells with generally distinct cell borders and a moderate amount of eosinophilic cytoplasm. Abdominal lesions were positive for Melan A. Dorsal and forelimb lesions were positive for CD3. This study reports the occurrence of epitheliotropic cutaneous T-cell lymphoma and malignant melanoma in a crossbred Boxer dog and discusses the importance of performing immunohistochemical profile to confirm the phenotype of the tumor.
Highlights
Lymphoma is a cancer of hematopoietic origin often observed in dogs; its cutaneous presentation is very unusual, occurring in approximately 5% of the total cases of lymphoma in this species (Moore and Olivry, 1994)
Due to its clinical heterogeneity and microscopic findings, epitheliotropic cutaneous T-cell lymphoma can be further subdivided into three variants, known as mycosis fungoides, Sezary syndrome and pagetoid reticulosis (Moore et al, 2009)
This study reports the occurrence of epitheliotropic cutaneous T-cell lymphoma and malignant melanoma in a Boxer dog and discusses the importance of performing immunohistochemical profile to confirm the tumor phenotype
Summary
Lymphoma is a cancer of hematopoietic origin often observed in dogs; its cutaneous presentation is very unusual, occurring in approximately 5% of the total cases of lymphoma in this species (Moore and Olivry, 1994). Melanomas are relatively common tumors of melanocytes and melanoblasts (Bostock, 1986), representing 6.2% of cases of skin cancer in dogs (Vail and Withrow, 2007). Due to its clinical heterogeneity and microscopic findings, epitheliotropic cutaneous T-cell lymphoma can be further subdivided into three variants, known as mycosis fungoides, Sezary syndrome and pagetoid reticulosis (Moore et al, 2009). Mycosis fungoides is the most common variant of epitheliotropic cutaneous T-cell lymphoma, being distinguished by a prominent epitheliotropic lymphocytic tumor. This study reports the occurrence of epitheliotropic cutaneous T-cell lymphoma and malignant melanoma in a Boxer dog and discusses the importance of performing immunohistochemical profile to confirm the tumor phenotype
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