Abstract
BackgroundThere is no specific therapy for cutaneous epitheliotropic T-cell lymphoma (CETL). The administration of retinoids in conjunction with interferon-α (IFN-α) in CETL has not been reported in dogs.Case presentationTwo dogs (Shih tzu and Miniature pinscher) presented with multiple nodular skin lesions. Histopathological examination revealed diffuse infiltrations of lymphocytes in the epidermis and dermis, with a CD3-positive immunophenotypic profile. Based on the clinical and histopathological examination, CETL was diagnosed. Both dogs were treated with isotretinoin in combination with IFN-α and showed clinical improvement with complete or partial remission. The disease in these dogs was well-controlled for more than 264 days of overall median survival time without any additional clinical signs after initiation of the treatment. In both the cases, the dogs were followed up for 27 months, and 10 months without any evidence of recurrence or metastasis, respectively.ConclusionsWe describe the clinical efficacy of isotretinoin combined with IFN-α in 2 dogs with CETL. Long-term management with isotretinoin combined with IFN-α was effective in treating CETL in these cases.
Highlights
BackgroundCanine cutaneous lymphoma is a relatively uncommon form of lymphoma with an incidence of 3–8% of lymphoma, and 1% canine skin tumors [1,2,3]
There is no specific therapy for cutaneous epitheliotropic T-cell lymphoma (CETL)
We describe the clinical efficacy of isotretinoin combined with IFN-α in 2 dogs with Cutaneous epitheliotropic T-cell lymphoma (CETL)
Summary
Canine cutaneous lymphoma is a relatively uncommon form of lymphoma with an incidence of 3–8% of lymphoma, and 1% canine skin tumors [1,2,3]. In CETL, cytology samples can reveal large round cells with a high nucleo-cytoplasm ratio and prominent nucleoli with histological presence of cutaneous infiltration of malignant T lymphoid cells, especially in the epidermis and dermis [4]. In humans, it progresses through multiple stages starting with patches (patch stage), followed by plaques of variable thickness. 2 weeks later, there was marked improvement in the skin condition showing approximately more than 50% regression in the size of the nodules, termed as partial remission (Fig. 3b, d, f and h). The case was followed up for 10 months and there was no evidence of recurrence or metastasis
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