Abstract
This chapter focuses on epithelial transport. For any species, the ratio of presteady-state fluxes is equal to the steady-state flux ratio. This is true from the moment of first passage of the isotopes if only one pathway is available and if conditions along the path remain constant. This thesis is correct, independent of the mechanism responsible for the transport. This holds true whether dealing with electrodiffusion or active transport. The derivation is carried through for an arbitrary number of layers with arbitrary properties placed in series. Unstirred layers are included as additional series barriers. The two bathing solutions should, however, be well stirred and be of constant composition. If the isotope experiment shows that the flux ratio is changing with time, it can only mean that more than one pathway is available for the ion in question. The pathways must differ with respect to mean passage time as well as to flux ratio. The chapter presents an experiment in which the behavior of sodium fluxes through frog skin was studied.
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