Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain

V N Ochkolyas,A A Skoromets,A V Kostyukevich,A F Gurchin

doi:10.24884/1607-4181-2013-20-4-73-76

Abstract

The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate. Frequency and clinical features of symptomatic epilepsy, the reaction of AMPA receptors of glutamate depending on localization and degree of malignance and features of clinical course of the disease wereinvestigated as well. Marked increase of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate was noticed in the patients with gliomas associated with epileptic syndrome. Maximal level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate seen under the effect of the tumor on the frontal and temporal lobels.

Highlights

Human epidermal growth factor receptor (HER2/neu, c ErbB2) is a proto oncogene protein which is overexpressed in some oncological diseases including 30 % of breast cancers, tumors in the ovary, stomach and other organs of the human body as well
Since Her2 tumor status testing is the essential part of successful cancer treatment, expression and purification of substantial amounts of the extracellular domain of the ECD HER2 is an important task
Maximal level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate seen under the effect of the tumor on the frontal and temporal lobels

Summary

SUMMARY

Human epidermal growth factor receptor (HER2/neu, c ErbB2) is a proto oncogene protein which is overexpressed in some oncological diseases including 30 % of breast cancers, tumors in the ovary, stomach and other organs of the human body as well. Since Her tumor status testing is the essential part of successful cancer treatment, expression and purification of substantial amounts of the extracellular domain of the ECD HER2 is an important task. In this work sequence encoding HER2 extracellular domain was cloned and expressed in E.coli. Первый Санкт Петербургский государственный медицинский уни верситет имени академика И. П. Павлова; Институт мозга человека имени Н. Большую роль в клеточно молекулярных механизмах эпилеп тогенеза играют AMPA (α amino 3 hydroxy 5 methyl 4 isoxazolepropionicacid) ионотропные глю таматные рецепторы. Через рецепторы и сопря женные с ними ионные каналы натрия и кальция реализуется ионотропный эффект глютамата, яв ляющегося наиболее распространенным возбуж дающим нейротрансмиттером нервной системы [1, 2, 11].

Мозолистое тело с бифронтальным ростом

Анапластическая астроцитома

Анапластическая олигоастро цитома

Мозолистое тело с бифронтальным

Findings

Группа сравнения