Abstract
Background: Global emergence of SARS-CoV-2 surfaced neurological complications amongst the patients. COVID-19 resembles with other coronavirus strains follows a trend of neurological complication, damage and encephalopathy, which entails considerable risks, requires attention for the neurologists. This is, to our knowledge, the first systematic review of the literature to investigate solely to elucidate the seizure spectrum by unfolding epileptogenicity of the SARS CoV-2 and potential pathways of neuroinvasion.
 Methods: A systematic literature search was performed in PubMed and Embase database following standard guidelines, using specific keywords based on epileptic seizure onset described from December 01, 2019, to July 17, 2020
 Results: A total of 17 studies were included ranging from case reports, series of cases, multicentre cross-sectional study with the first-time onset of seizure associated with an epileptic origin. We excavated causes of complex COVID-19 related neurological manifestations, e.g., cerebrovascular diseases, encephalitis, demyelinating lesions, cytokine storm and proposed routes of SARS-CoV-2 entry into the nervous system to understand the mechanism of an epileptic seizure.
 Conclusion: COVID-19 is a potent neuropathogen which causes the new onset of epileptic seizures should get diagnostic recognition to evade possible deterioration of neurological conditions. However, more shreds of evidence from the future will further elucidate the epileptogenic potential of the pandemic.
Highlights
Background Global emergence of SARSCoV-2 surfaced neurological complications amongst the patients
COVID-19 is a potent neuropathogen which causes the new onset of epileptic seizures should get diagnostic recognition to evade possible deterioration of neurological conditions
After exclusion and eligibility of full text, 17 articles were selected for systematic review, involved seizures, or epilepsy as a new-onset due to SARS-CoV-2 infection
Summary
Background Global emergence of SARSCoV-2 surfaced neurological complications amongst the patients. COVID-19 resembles with other coronavirus strains follows a trend of neurological complication, damage and encephalopathy, which entails considerable risks, requires attention for the neurologists This is, to our knowledge, the first systematic review of the literature to investigate solely to elucidate the seizure spectrum by unfolding epileptogenicity of the SARS CoV-2 and potential pathways of neuroinvasion. The virus was named as Coronavirus disease 2019 "COVID-19" by the World Health Organization (WHO), affected 216 countries with 2,102,6758 confirmed cases and 75,5786 deaths as of August 16, 2020 [4] The spread of this virus and ongoing devastation around the world shows no evidence of ending of this global pandemic and it impacted deadly on economic, financial, social, and mental wellbeing on the humanity. This systematic review aims to outline a spectrum of the seizures and epileptic symptoms of SARS-CoV-2 infected patients and enlighten the viral invasion to CNS and mechanism of epileptogenicity
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