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https://doi.org/10.1016/j.ejpn.2017.04.767
Copy DOIPublication Date: Jun 1, 2017 | |
Citations: 1 |
Objective: To research age of epilepsy onset in puberty in girls. Methods: Research was a part of prospective observational uncontrolled comparative study of the antiepileptic drugs reproductive side effects. The age of epilepsy onset were studied in 155 female patients in reproductive age. 3 groups of puberty age and 4 subgroups of puberty period were allocated. STATISTICA for Windows system (version 5.5) was used. Results: Patients were divided into three groups according WHO classification of puberty age (1997): 1gr. – before puberty- 1–9y.o., 2gr. – puberty- 10–18, 3g. – after puberty- older 18. There were 23 patients (15%) in 1 gr., 92 (59%) – in 2gr, 40 (26%) – in 3 gr. Differences in the epilepsy onset in the comparison groups were statistically significant above in puberty (p<0,001). Epilepsy began in childhood (until 18 y.o) in 75%. Frequency of epilepsy onset was studied in 4 subgroups of puberty period according phases of maturing of hypothalamo-hypophysial system: 10–11y.o- beginning of hypothalamo- hypophysial hormones secretion , 12-13 – beginning menses, 14-15- becoming of ovulatory peak, 17-18- establishment of a constant rhythm of hormones secretion. There were 18 patients (20%) into 1subgr., 35 (38%) – 2nd, 24 (26%)- 3d, 15 (16%) into 4 subgroup. Prevalence of epilepsy onset in the integrated age range of 12-16 years was statistically reliable (p<0,001). Conclusion: Thus, hormonal changes during the puberty period often provoked epilepsy onset. The epilepsy onset prevailed during the periods of the beginning oestradiolum production and its ovulatory peaks. It has confirmed estrogens proconvulsive effect. The reported study was funded by Russian humanitarian scientific fund according to the research project № 15-06-10816.
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