Abstract
Epigenome-Wide Association Studies (EWAS) are furthering our knowledge of epigenetic modifications involved in the regulation of lipids’ metabolism. Furthermore, epigenetic patterns associated with lipid levels may play an important role in predicting the occurrence of cardiovascular events. To further investigate the relationship between methylation status and lipids, we performed an EWAS in 211 individuals from the STANISLAS Family study (SFS). Methylation at two CpG sites (PRKAG2; p = 1.39 × 10−8; KREMEN2; p = 5.75 × 10−9) were significantly associated with lipidomic profiles. Replication was sought in adipose tissue where one probe, cg08897188, was found to be nominally significant (KREMEN2; p = 0.0196). These results could provide new insight in the mechanisms underlying cardiovascular diseases and contribute to new therapeutic interventions.
Highlights
Our health and well-being depend on diverse interactions between clinical, biological, environmental and lifestyle factors, which, all together, are involved in complex pathological mechanisms that may influence the disease susceptibility, development and prognosis of the treatment [1]
Type-2 diabetes patients and individuals suffering from infectious diseases (e.g., AIDS and tuberculosis) were characterized by abnormal profiles of high triglycerides (TG), low levels of high density lipoprotein (HDL), high serum levels of very low density lipoproteins (VLDL) and increased LDL [2]
A differentially methylated locus was associated with cardiovascular diseases (CVD) events. These findings demonstrate an important role of epigenetic patterns in lipid metabolism and in predicting the occurrence of CVD events [14]
Summary
Our health and well-being depend on diverse interactions between clinical, biological, environmental and lifestyle factors, which, all together, are involved in complex pathological mechanisms that may influence the disease susceptibility, development and prognosis of the treatment [1]. Dysregulated lipid levels, commonly referred to as dyslipidemia, are one of the leading risk factors for cardiovascular diseases (CVD), and influence other chronic conditions such as type-2 diabetes mellitus [2]. TG are becoming the subject of new investigations in order to improve diagnosis and, potentially, in the prevention and treatment of CVD. Their predictive value for the onset of the pathology is considered to be even higher than that of cholesterol [4,5]. Potential new medications for the normalization of TG levels could be developed and used together with statins to help further reduce risk of chronic diseases. The study of factors affecting lipids’ levels is an important field in the fight against CVD and other morbidities
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call