Abstract
We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study of stable alterations in gene expression potential that arise during development and cell proliferation. Epigenetic changes are modifications of DNA, which occur without any alteration in the DNA sequence. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different types. Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. If epigenetic process are reversible, than there is the ability to cure cancer through stem cell therapy.
Highlights
Received: 23.11.2012Provisionally accepted: 28.02.2013 Epigenetics is defined as heritable changes in gene expression that are Accepted: 04.03.2013 not accompanied by changes in DNA sequence
Accepted: 28.02.2013 Epigenetics is defined as heritable changes in gene expression that are Accepted: 04.03.2013 not accompanied by changes in DNA sequence
The importance of processes identifies postsynthetic modification of either the DNA itself or these factors for gene regulation and other processes with chromatin of proteins that intimately associate with DNA as the key mediators (1, 2). substrate has emerged from genetic studies
Summary
Milanko Stupar[1], Vitomir Vidović[1], Vladimir Baltić[2], Ljuba Štrbac[1], Dragomir Lukač[1]
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