Abstract
The Ceylon Journal of Science is a peer-reviewed journal published quarterly by the University of Peradeniya, Sri Lanka in March, June, September and December. It is aimed at publishing high quality research articles on topics related to different disciplines in Science. The journal accepts original research articles, book reviews, reviews and mini-reviews, short communications, opinions, research notes, and commentaries and notes. The Journal has its own website https://site.pdn.ac.lk/cjs/. The journal strictly adheres to publication ethics as emphasized by the Committee on Publication Ethics (COPE). It is indexed in Sri Lanka Journals Online (SLJOL), Directory of Open Access Journals (DOAJ), Google Scholar and Zoological Records. According to the Google Scholar;H5-Index: 12H5-Median: 15According to the Exaly (1970 – 2021);Impact Factor: 0.6 (top 19%)Extended IF: 0.6 (top 19%)H-Index: 8 (top 28%)Citations/paper: 1.42
Highlights
Following completion of the sequencing of the human genome in 2001 attempts were made to decipher functional units imprinted in the genome, their regulation, and deregulation that caused disease
The genetic information inherited from the parents provides the blueprint for the synthesis of all proteins necessary for human life while epigenetic information instructs how, where and when genetic information should be used (Robertson, 2001)
Humans respond to infection by initiating inflammatory and immune responses whereby infecting organism is cleared from the system (Nicholson, 2016) In cases of resistance to such actions, pathogens are seen to develop mechanisms to modify host cell functionality to promote their survival and, in the case of intracellular pathogens, to generate a suitable environment for them to replicate within the host
Summary
Epigenetic changes in health and disease: DNA Methylation in human development, infection and non-communicable diseases.
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