Abstract
The Ceylon Journal of Science is a peer-reviewed journal published quarterly by the University of Peradeniya, Sri Lanka in March, June, September and December. It is aimed at publishing high quality research articles on topics related to different disciplines in Science. The journal accepts original research articles, book reviews, reviews and mini-reviews, short communications, opinions, research notes, and commentaries and notes. The journal strictly adheres to publication ethics as emphasized by the Committee on Publication Ethics (COPE). The Journal has its own website.The Ceylon Journal of Science is indexed in Sri Lanka Journals Online (SLJOL), Directory of Open Access Journals (DOAJ), Google Scholar and Zoological Records. According to the Google Scholar; H5-Index: 12H5-Median: 15According to the Exaly (1970 – 2021); Impact Factor: 0.6 (top 19%)Extended IF: 0.6 (top 19%) H-Index: 8 (top 28%)Citations/paper: 1.42
Highlights
The human body is home to over 100 trillion bacterial cells, fungi, and viruses that constitute the human microbiome found on various epithelial surfaces (Ley et al, 2006)
A similarity between microbial profiles of responders has been observed in studies conducted for different cancer types (Routy et al, 2017; Gopalakrishnan et al, 2018). This suggests that the commensal species of Clostridales and Bacteroidales orders, belonging to the phyla Firmicutes and Bacteroidetes provide beneficial effects on anti programmed cell death-1 (PD-1) therapy irrespective of the type of cancer targeted by Immune checkpoint inhibitor (ICI) based immunotherapy (Humphries and Daud, 2018)
Even though antibiotics are recommended to eliminate harmful bacteria, they may contribute to dysbiosis because they may inhibit the beneficial microflora since their activity is nonspecific
Summary
Effect of gut microbiota on immune checkpoint inhibitor (ICI) based cancer immunotherapy.
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