Epidemiology of infective endocarditis in Portugal, a populational study

Abstract

Abstract Introduction Infective endocarditis (IE) diagnosis and management continues to be a challenge. Purpose Describe temporal trends on the incidence of infective endocarditis, its clinical and outcome results, in Portugal. Methods A nationwide retrospective temporal trend study on the incidence and clinical characterization of patients hospitalized with infective endocarditis – 2010 to 2018, in Portugal. Results 7574 hospitalized patients with infective endocarditis from 2010 to 2018 in Portuguese public hospitals. Predominantly men (56.9%), and 47.1% were between 60 and 79 years old. The most frequent infectious agents involved were Staphylococcus (16.4%) and Streptococcus (13.6%). During hospitalization, 12.4% of patients underwent heart valve surgery and 20% of the total cohort died. The annual incidence of infective endocarditis was 8.31 per 100,000 habitants, being higher in men and increased with age. In-hospital mortality rate significantly increased, the strongest independent predictors being ischemic or hemorrhagic stroke, sepsis, acute renal failure and older age. Conclusions In Portugal, between 2010 and 2018, the incidence of infective endocarditis presented a general growth trend with a deceleration in the most recent years. A significant rate of in-hospital complications, a mildly lower than expected stable surgical rate and a still high and growing mortality rate were noted. Funding Acknowledgement Type of funding sources: None.